IV iron sucrose vs oral ferrous sulfate in IBD anemia

What is known

• A randomized, controlled, evaluator-blind IBD study concluded IV iron sucrose is superior to oral iron sulfate for correcting anaemia and restoring iron stores. ¹
• In randomized trials, IBD patients receiving iron sucrose are more likely to achieve resolution of anemia and normalization of ferritin than those on oral iron. ²
• Several IBD studies found IV iron more effective at increasing Hb with lower treatment-related adverse events. ²

What is unknown / caveats

• Excerpts describe effectiveness/completeness of anemia correction, not a direct time-to-recovery (rate of Hb rise) comparison
• Underlying randomized trials are cited but their numeric Hb-recovery timelines are not given in the excerpts
• The excerpts do not quantify how much faster, if at all, iron sucrose raises hemoglobin compared with oral ferrous sulfate.

References

1. Magro F, Ramos J, Correia L, Lago P, Peixe P, Gonçalves AR, Rodrigues Ã, Vieira C, Ferreira D, Pereira Silva J, Túlio MA, Salgueiro P, Fernandes S. [Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease]. Acta Med Port. 2016. PMID: 27234956.

2. Bohm N. Diagnosis and management of iron deficiency anemia in inflammatory bowel disease. Am J Manag Care. 2021. PMID: 34255450.

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Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct.