Top 100 Most Cited

The 100 most-cited papers across the EIM literature, by citation count (NIH Open Citation Collection).

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the IBD extraintestinal-manifestations literature.

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

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1Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
2012 · Nature
3,758
2The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy.
1991 · Arthritis Rheum
1,922
3Crohn's disease.
2012 · Lancet
1,626
4TNF-mediated inflammatory disease.
2008 · J Pathol
1,528
5Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders
Magro · 2017 · J Crohns Colitis
1,445
6Inflammatory bowel disease: clinical aspects and established and evolving therapies
Baumgart · 2007 · Lancet
1,444
7Therapeutic roles of curcumin: lessons learned from clinical trials.
2013 · AAPS J
1,278
8The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general.
2011 · Ann Rheum Dis
1,236
9Tumor necrosis factor antagonist mechanisms of action: a comprehensive review.
2008 · Pharmacol Ther
1,230
10The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
1,063
11Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol
1,020
12Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.
2004 · Gastroenterology
975
13Development and validation of a pediatric Crohn's disease activity index.
1991 · J Pediatr Gastroenterol Nutr
964
14Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
2010 · Nature
924
15Intestinal inflammation and cancer.
Ullman TA · 2011 · Gastroenterology
915
16Diagnosis and management of primary sclerosing cholangitis.
2010 · Hepatology
875
17Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
2009 · Altern Med Rev
836
18Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
2015 · N Engl J Med
807
19European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
2015 · J Eur Acad Dermatol Venereol
807
20CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
2002 · Am J Hum Genet
795
21ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
2023 · Ann Rheum Dis
786
22Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
2021 · Nat Rev Immunol
756
23CARD15 mutations in Blau syndrome.
2001 · Nat Genet
748
24Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
Chapman RW · 1980 · Gut
740
25Risk factors for cholangiocarcinoma.
2011 · Hepatology
715
26Primary sclerosing cholangitis - a comprehensive review.
2017 · J Hepatol
670
27Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
2021 · Gastroenterology
659
28Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis.
2003 · Rheumatol Int
639
29Spondyloarthritis.
2011 · Lancet
632
30Behçet's disease. Report of 41 cases and a review of the literature.
1975 · Medicine (Baltimore)
609
31Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
2016 · Nat Genet
585
32Inflammatory Bowel Disease in Children and Adolescents.
2015 · JAMA Pediatr
581
333rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 2: Surgical Management and Special Situations.
Gionchetti P · 2017 · J Crohns Colitis
579
34The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease.
2016 · J Crohns Colitis
570
35Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.
2007 · Medicine (Baltimore)
569
36The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study.
2001 · Am J Gastroenterol
567
37Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis.
2013 · Hepatology
560
38PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis.
Loftus · 2005 · Gut
558
39Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials.
2022 · Lancet
541
40Ulcerative Colitis in Adults: A Review.
Gros · 2023 · JAMA
527
41Hepatic and extrahepatic malignancies in primary sclerosing cholangitis.
2002 · J Hepatol
526
42Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis.
1989 · Hepatology
506
43Extraintestinal Manifestations of Inflammatory Bowel Disease.
2015 · Inflamm Bowel Dis
501
44New IBD genetics: common pathways with other diseases.
2011 · Gut
497
45Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021.
2022 · Nat Rev Rheumatol
477
46Associations between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies, and Behcet's syndrome.
1974 · Medicine (Baltimore)
476
47Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.
1993 · Drugs
470
48Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas.
1991 · Hum Pathol
466
49How to diagnose axial spondyloarthritis early.
2004 · Ann Rheum Dis
465
50THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS.
1964 · Gut
464
51Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial.
2006 · Gut
464
52Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review.
2012 · J Hepatol
462
53Primary sclerosing cholangitis.
2013 · Lancet
454
54National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications.
Rankin GB · 1979 · Gastroenterology
443
55Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease.
2013 · Ann Rheum Dis
439
56Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis.
2002 · Gastrointest Endosc
439
57Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study.
2001 · Hepatology
439
58An update on the epidemiology of inflammatory bowel disease in Asia.
2008 · Am J Gastroenterol
437
59Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database.
Vind · 2006 · Am J Gastroenterol
430
60Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis.
Farmer RG · 1985 · Gastroenterology
428
61Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
2013 · Nat Genet
428
62Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort.
2011 · Am J Gastroenterol
423
63Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years.
2012 · Gastroenterology
422
64European evidence based consensus on the diagnosis and management of Crohn's disease: current management.
2006 · Gut
421
65Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.
Weismüller · 2017 · Gastroenterology
412
66Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.
2003 · Gastroenterology
393
67Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Turner · 2018 · J Pediatr Gastroenterol Nutr
387
68Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?
2004 · Gut
386
69A comprehensive review and update on Crohn's disease.
Gajendran M · 2018 · Dis Mon
382
70Pyoderma gangrenosum: a review of 86 patients.
1985 · Q J Med
379
71Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.
2019 · J Am Acad Dermatol
376
72Loss of response and need for adalimumab dose intensification in Crohn's disease: a systematic review.
2011 · Am J Gastroenterol
375
73Crohn Disease: Epidemiology, Diagnosis, and Management.
Feuerstein JD · 2017 · Mayo Clin Proc
374
74Current concepts. Primary sclerosing cholangitis.
1984 · N Engl J Med
373
75Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis
Penna · 1996 · Gut
371
76ACG Clinical Guideline: Primary Sclerosing Cholangitis.
2015 · Am J Gastroenterol
361
77Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
2019 · Nat Microbiol
360
78Primary sclerosing cholangitis.
2018 · Lancet
356
79The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls.
2017 · Gut
352
80Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer.
2006 · Dan Med Bull
350
81Smoking habits and recurrence in Crohn's disease.
1994 · Gastroenterology
349
82Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.
2020 · Cell
348
83Update on spondyloarthropathies.
2002 · Ann Intern Med
347
84Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L · 2016 · Clin Gastroenterol Hepatol
346
85Clinical features and natural history of Crohn's disease.
Mekhjian HS · 1979 · Gastroenterology
345
86Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies.
2008 · World J Gastroenterol
344
87Pyoderma gangrenosum: an updated review.
2009 · J Eur Acad Dermatol Venereol
344
88Extraintestinal manifestations of inflammatory bowel disease.
2011 · Gastroenterol Hepatol (N Y)
340
89Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.
2001 · Ann Intern Med
337
90Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD.
2016 · Gut
336
91Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential.
1995 · Hepatology
336
92Covid-19 in Immune-Mediated Inflammatory Diseases - Case Series from New York.
2020 · N Engl J Med
335
93Ulcerative Colitis.
2019 · Mayo Clin Proc
327
94Optimizing anti-TNF treatment in inflammatory bowel disease.
Rutgeerts P · 2004 · Gastroenterology
327
95American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
2016 · Arthritis Rheumatol
323
96Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz Steven · 2004 · Gastroenterology
322
97Recent insights into the genetics of inflammatory bowel disease.
Cho JH · 2011 · Gastroenterology
321
98Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community.
2003 · Gastroenterology
320
99Prevalence of extra-articular manifestations in patients with ankylosing spondylitis: a systematic review and meta-analysis.
2015 · Ann Rheum Dis
319
100Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies
Triantafillidis · 2009 · Anticancer Res
318