Does intravenous iron sucrose lead to faster hemoglobin recovery than oral ferrous sulfate in patients with iron deficiency anemia secondary to IBD

What is known

- A randomized, controlled, evaluator-blind IBD study concluded IV iron sucrose is superior to oral iron sulfate for correcting anaemia and restoring iron stores. ¹ - In randomized trials, IBD patients receiving iron sucrose are more likely to achieve resolution of anemia and normalization of ferritin than those on oral iron. ² - Several IBD studies found IV iron more effective at increasing Hb with lower treatment-related adverse events. ²

What is unknown / caveats

- Excerpts describe effectiveness/completeness of anemia correction, not a direct time-to-recovery (rate of Hb rise) comparison - Underlying randomized trials are cited but their numeric Hb-recovery timelines are not given in the excerpts - The excerpts do not quantify how much faster, if at all, iron sucrose raises hemoglobin compared with oral ferrous sulfate.

## References

1. Magro F, Ramos J, Correia L, Lago P, Peixe P, Gonçalves AR, Rodrigues Ã, Vieira C, Ferreira D, Pereira Silva J, Túlio MA, Salgueiro P, Fernandes S. [Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease]. Acta Med Port. 2016. PMID: 27234956.

2. Bohm N. Diagnosis and management of iron deficiency anemia in inflammatory bowel disease. Am J Manag Care. 2021. PMID: 34255450.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._